The relationship between stress, aging and epigenetics reveals how various stressors influence cellular mechanisms and contribute to age-related diseases.
An in-depth analysis of recent studies highlights the crucial importance of understanding these interactions to develop effective interventions against aging and its associated conditions.
Stressors, such as oxidative and genotoxic stress, are major gas pedals of aging, with epigenetic alterations playing an important role in age-related changes in gene expression and cellular homeostasis.
Although epigenetic alterations are observed in individuals under chronic or repeated stress, and are associated with premature aging and an increased risk of age-related diseases, it remains to be determined whether these epigenetic changes are a direct cause of accelerated aging or simply markers associated with the process.
The complexity of the links between stress, aging and epigenetics underscores the fundamental importance of understanding these interactions to develop therapeutic interventions against age-related diseases.
Continued research and the establishment of uniform standards will enable us to better understand these mechanisms and develop effective strategies to mitigate the effects of aging on health.
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Sources:
Stress, epigenetics, and aging: Unraveling the intricate crosstalk.
Wu Z, Qu J, Zhang W, Liu GH.
Mol Cell. 2024 Jan 4;84(1):34-54. doi: 10.1016/j.molcel.2023.10.006.
https://www.cell.com/molecular-cell/fulltext/S1097-2765(23)00809-2?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1097276523008092%3Fshowall%3Dtrue